Trubitsyna IE*, Vorobyeva NN, Lesko KAM, Smirnov AV, Vinokurova LD
Loginov Department of Health of Moscow, Moscow Clinical Research Center named after A.S, Moscow, Russia
*Corresponding Author: Trubitsyna IE, Loginov Department of Health of Moscow, Moscow Clinical Research Center named after A.S, Moscow, Russia; Email: [email protected]
Received Date: September 5, 2023
Publication Date: September 19, 2023
Citation: Trubitsyna IE, et al. (2023). Endo- and Exoantigens and Development of Autoimmune Reaction. Clin Res. 4(4):18.
Copyright: Trubitsyna IE, et al. © (2023).
The immunoinflammatory response is involved in the formation structural damage in organs with low immune resistance, but the stages of formation of this reaction are bad studied. In patients with acute and chronic pancreatitis alcohol etiology causes a reactive inflammatory reaction in the mucous membrane of the small intestine. Clarification of all stages of development of comorbidity forced to conduct experimental studies that were carried out on 45 white Wistar rats weighing 180-220 g under conditions mucous membrane (MM) of the stomach and duodenum. A feature of this study was that the animals were previously immunized according to the classical immunization schedule, with pancreatic homogenates (PG), different sections mucous membrane of the stomach (MM S) or duodenum (MM D). Rats were removed from the experiment on days 5, 10 and 20. Undoubtedly, the presence of damage to the pancreas promotes the development of an autoimmune reaction, in response to destruction and inflammatory response. Structural and functional damage to one’s own tissues occurs in other organs. The participation of several organs in a joint reaction depends from the immune tolerance of the organ to exo- and endoantigens. The presence of concomitant pathology it is not always possible to determine the “primary” organ that contributed to the formation of the autoimmune reaction. At the same, antibodies to endoantigens are formed from damaged tissues.
Keywords: endo- and exoantibodies, autoimmune reaction, pancreatitis, gastric and duodenal mucosa